hrp0082p1-d3-162 | Growth (2) | ESPE2014

Infliximab Improves Growth in Paediatric Crohn’s disease Only if Commenced Early in Puberty or Prior to the Onset of Puberty

Gangadharan Arundoss , Metcalf Joanna , Giri Dinesh , Irving Sharon , Auth Marcus , Venkatesh Krishnappa , Krishnamurthy Balaji , Blair Joanne C , Didi Mohammed

Background: Crohn’s disease is a relapsing systemic inflammatory disorder with inflammatory bowel disease (IBD) due to up-regulation of pro-inflammatory cytokines including TNFα. More than 80% of newly diagnosed children present with growth failure Paediatric gastroenterology units in the UK submit data to the UK IBD database which can be accessed when required. One aim of current treatment protocols is to promote growth. Studies on the use of anti-TNFα antibodi...